Advanced Depression Care
Ketamine and Esketamine Therapy in Frederick, Maryland
Ketamine and FDA-approved esketamine, marketed as Spravato, are options for some patients with treatment-resistant depression. Maryland Wellness Psychiatry approaches these treatments carefully, with thorough evaluation, realistic expectations, and close medical monitoring for patients in Frederick and across Maryland.
2019
Year the FDA approved esketamine for treatment-resistant depression
Supervised
Esketamine is given in a certified, monitored medical setting
Adjunct
Used alongside an oral antidepressant, not as a standalone fix
Key Capabilities
- •Thorough evaluation to assess candidacy for ketamine or esketamine
- •Clear education on benefits, limits, and realistic expectations
- •Screening for medical and psychiatric factors that affect safety
- •Coordination with oral antidepressants and ongoing treatment
- •Monitoring of blood pressure, sedation, and response on treatment days
- •Referral or coordination for certified administration where appropriate
Why It Matters
A Different Mechanism
Ketamine and esketamine act on glutamate signaling rather than the serotonin pathways targeted by standard antidepressants, which is why some patients respond when other medications have not.
Careful, Honest Expectations
These treatments are not cures and do not work for everyone. We discuss the evidence plainly so you can make an informed decision rather than relying on overstated promises.
Safety Comes First
Esketamine is delivered in a supervised setting with monitoring, and patients should not drive afterward on treatment days. Structured oversight reduces risk and supports appropriate use.
Part of a Complete Plan
Ketamine-based options work best within a broader strategy that may include medication management, therapy, and other tools, all coordinated by your psychiatrist.
Frequently Asked Questions
What is ketamine therapy used for in psychiatry?
Ketamine and its FDA-approved nasal-spray form esketamine, marketed as Spravato, are used for certain cases of treatment-resistant depression and, in specific settings, depression with suicidal thoughts. They are considered when standard antidepressants have not provided adequate relief, and they are always used under medical supervision.
How is esketamine different from intravenous ketamine?
Esketamine, or Spravato, is an FDA-approved nasal spray given in a certified, monitored setting alongside an oral antidepressant. Intravenous ketamine for depression is used off-label. The right option depends on your history, and a psychiatric evaluation is needed to determine whether either is appropriate.
Is ketamine therapy a guaranteed cure for depression?
No. Ketamine and esketamine are not cures and do not help everyone. They are one option within a broader plan, and response varies from person to person. Careful evaluation, monitoring, and realistic goal-setting are essential, and benefits are typically maintained alongside other treatments.
What does monitoring involve?
Esketamine is administered in a supervised medical setting where blood pressure and sedation are monitored, and patients cannot drive afterward on treatment days. A psychiatrist screens for medical and psychiatric factors beforehand and reviews response over time. Safety monitoring is a core part of the process.